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Serological Stratification by Anti-Ro52 and Anti-Ro60 Profiles Reveals Distinct Systemic Phenotypes in Primary Sjögren's Disease.

Seminars in arthritis and rheumatism - 1 Apr 2026

Zhang Qingfeng, Zhang Liupan, Lv Luyao, Chen Daidi, Yang Zirui, Yi Wenqian, Jia Zhuoyang, Feng Xuebing

Abstract excerpt

BACKGROUND: Anti-Ro52 and anti-Ro60 antibodies are key serological markers for primary Sjögren's disease (pSjD), yet their association with specific clinical phenotypes remains unclear. This study aimed to define the predictive value of anti-Ro profiles for systemic involvement in pSjD. METHODS: In this retrospective study of 725 pSjD patients, we categorized patients into four subgroups based on their...

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PMID: 41707292
DOI: 10.1016/j.semarthrit.2026.152942

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SI

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