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Article

Pathogenicity and proteomic signatures of autoantibodies to Ro and La

17 Jan 2012

Abstract excerpt

Ro/SSA and La/SSB comprise a linked set of autoantigens that are clinically important members of the extractable nuclear antigen family and key translational biomarkers for lupus and primary Sjögren's syndrome. Autoantibodies directed against the Ro60 and La polypeptide components of the Ro/La ribonucleoprotein complex, and the structurally unrelated Ro52 protein, mediate tissue damage in the neonatal lupus...

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PMID: 22249199
DOI: 10.1038/icb.2011.108

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