Article
IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2005
Khader Shabaana A, Pearl John E, Sakamoto Kaori, Gilmartin Leigh, Bell Guy K, Jelley-Gibbs Dawn M, Ghilardi Nico, deSauvage Fred, Cooper Andrea M
Abstract excerpt
IL-12p70 induced IFN-gamma is required to control Mycobacterium tuberculosis growth; however, in the absence of IL-12p70, an IL-12p40-dependent pathway mediates induction of IFN-gamma and initial bacteriostatic activity. IL-23 is an IL-12p40-dependent cytokine containing an IL-12p40 subunit covalently bound to a p19 subunit that is implicated in the induction of CD4 T cells associated with autoimmunity and...
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