Article
IL-23-driven encephalo-tropism and Th17 polarization during CNS-inflammation in vivo.
European journal of immunology - 1 Jul 2009
Gyülvészi Gabor, Haak Stefan, Becher Burkhard
Abstract excerpt
IL-23 but not IL-12 is essential for the development of autoimmune tissue inflammation in mice. Conversely, IL-12 and IL-23 impact on the polarization of Th1 and Th17 cells, respectively. While both polarized T helper populations can mediate autoimmune inflammation, their redundancy in the pathogenesis of EAE indicates that IL-23 exerts its crucial influence on the disease independent of its T helper polarizing...
Topics
- Animals
- Bone Marrow
- CD4-Positive T-Lymphocytes
- Central Nervous System
- Encephalomyelitis, Autoimmune, Experimental
- Flow Cytometry
- Forkhead Transcription Factors
- Homeodomain Proteins
- Interferon-beta
- Interleukin-17
- Interleukin-23
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mutation
- Receptors, Interleukin
- Receptors, Interleukin-12
- Signal Transduction