Article
IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2002
Gran Bruno, Zhang Guang-Xian, Yu Shuo, Li Jifen, Chen Xiao-Han, Ventura Elvira S, Kamoun Malek, Rostami Abdolmohamad
Abstract excerpt
Experimental autoimmune encephalomyelitis (EAE) serves as a model for multiple sclerosis and is considered a CD4(+), Th1 cell-mediated autoimmune disease. IL-12 is a heterodimeric cytokine, composed of a p40 and a p35 subunit, which is thought to play an important role in the development of Th1 cells and can exacerbate EAE. We induced EAE with myelin oligodendrocyte glycoprotein (MOG) peptide 35-55 (MOG(35-55))...
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