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Article

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

14 Dec 2018

Abstract excerpt

have similar frequencies of deleterious variants in the general population. The comparative rarity of symptomatic patients with IL-12Rβ2 or IL-23R deficiency, relative to IL-12Rβ1 deficiency, is, therefore, due to lower clinical penetrance. There are fewer symptomatic IL-23R- and IL-12Rβ2-deficient than IL-12Rβ1-deficient patients, not because these genetic disorders are rarer, but because the isolated absence of...

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PMID: 30578351
DOI: 10.1126/sciimmunol.aau6759

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