Article
Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2010
Wilson Mark S, Feng Carl G, Barber Daniel L, Yarovinsky Felix, Cheever Allen W, Sher Alan, Grigg Michael, Collins Mary, Fouser Lynette, Wynn Thomas A
Abstract excerpt
IL-22 is a member of the IL-10 cytokine family and signals through a heterodimeric receptor composed of the common IL-10R2 subunit and the IL-22R subunit. IL-10 and IL-22 both activate the STAT3 signaling pathway; however, in contrast to IL-10, relatively little is known about IL-22 in the host response to infection. In this study, using IL-22(-/-) mice, neutralizing Abs to IL-22, or both, we show that IL-22 is...
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