Article
Trapping of BMP receptors in distinct membrane domains inhibits their function in pulmonary arterial hypertension.
American journal of physiology. Lung cellular and molecular physiology - 1 Aug 2011
Jiang Yaxin, Nohe Anja, Bragdon Beth, Tian Chunhong, Rudarakanchana Nung, Morrell Nicholas W, Petersen Nils O
Abstract excerpt
Bone morphogenetic proteins (BMPs) are pleiotrophic growth factors that influence diverse processes such as skeletal development, hematopoiesis, and neurogenesis. They play crucial roles in diseases such as pulmonary arterial hypertension (PAH). In PAH, mutants of the BMP type II receptors (BMPR2) were detected, and their functions were impaired during BMP signaling. It is thought that expression levels of these...
Topics
- Animals
- Bone Morphogenetic Protein Receptors, Type II
- Bone Morphogenetic Proteins
- Caveolae
- Cell Line
- Cell Membrane
- Coated Pits, Cell-Membrane
- Familial Primary Pulmonary Hypertension
- Humans
- Hypertension, Pulmonary
- Mutation
- Phosphorylation