Article
Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension.
Circulation - 12 Jun 2007
Zakrzewicz Anna, Hecker Matthias, Marsh Leigh M, Kwapiszewska Grazyna, Nejman Bozena, Long Lu, Seeger Werner, Schermuly Ralph T, Morrell Nicholas W, Morty Rory E, Eickelberg Oliver
Abstract excerpt
BACKGROUND: Pulmonary arterial hypertension (PAH) is characterized by selective elevation of pulmonary arterial pressure. The pathological hallmark of PAH is the narrowing of pulmonary arterioles secondary to endothelial cell dysfunction and smooth muscle cell proliferation. Heterozygous mutations in BMPR2, encoding the type II bone morphogenetic protein receptor (BMPRII), were identified in PAH, suggesting that...
Topics
- Adult
- Animals
- Bone Morphogenetic Protein Receptors, Type II
- Cell Proliferation
- Down-Regulation
- Female
- GTP-Binding Proteins
- Humans
- Hypertension, Pulmonary