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Article

Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension.

Molecular biology of the cell - 1 Sept 2002

Nishihara Ayako, Watabe Tetsuro, Imamura Takeshi, Miyazono Kohei

Abstract excerpt

Germline mutations in the BMPR2 gene encoding bone morphogenetic protein (BMP) type II receptor (BMPR-II) have been reported in patients with primary pulmonary hypertension (PPH), but the contribution of various types of mutations found in PPH to the pathogenesis of clinical phenotypes has not been elucidated. To determine the biological activities of these mutants, we performed functional assays testing their...

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Identifiers

PMID: 12221115
DOI: 10.1091/mbc.e02-02-0063
PMCID: PMC124142

Genes

BMPR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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