Article

Saracatinib and Dasatinib Fail To Prevent Heritable Pulmonary Arterial Hypertension

2018-06-12

Abstract excerpt

Evidence suggests that the deregulation of SRC Family Kinases may play a role in the development of heritable pulmonary arterial hypertension, associated with BMPR2 mutations. The truncated c-terminus of the BMPR2 protein is known to increase the phosphorylation and downstream activity of SRC tyrosine kinases. To test the hypothesis that the inhibition of SRC can prevent heritable PAH due to a BMPR2 mutation, we e...

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Literature Corpus work: d43938fa-55c0-5787-bac4-d5d09a95d6fa
DOI: 10.1101/345447

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