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Article

Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1.

The Journal of cell biology - 15 Sept 2003

Foletta Victoria C, Lim Mei Ann, Soosairajah Juliana, Kelly April P, Stanley Edouard G, Shannon Mark, He Wei, Das Supratik, Massague Joan, Bernard Ora, Soosairaiah Juliana

Abstract excerpt

Bone morphogenetic proteins (BMPs) regulate multiple cellular processes, including cell differentiation and migration. Their signals are transduced by the kinase receptors BMPR-I and BMPR-II, leading to Smad transcription factor activation via BMPR-I. LIM kinase (LIMK) 1 is a key regulator of actin dynamics as it phosphorylates and inactivates cofilin, an actin depolymerizing factor. During a search for...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 12963706
DOI: 10.1083/jcb.200212060
PMCID: PMC2172847

Genes

LIMK1
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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