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Article

Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptotic cell death.

DNA repair - 28 Sept 2005

Horton Julie K, Stefanick Donna F, Wilson Samuel H

Abstract excerpt

The activity of poly(ADP-ribose) polymerase (PARP) is highly stimulated following DNA damage resulting in formation of DNA nicks and strand breaks. This leads to modification of numerous proteins, including itself, using NAD(+) as substrate and to exhaustion of intracellular ATP. A highly cytotoxic concentration of the DNA methylating agent methyl methanesulfonate (MMS) results in cellular ATP depletion and cell...

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Identifiers

PMID: 16002346
DOI: 10.1016/j.dnarep.2005.05.011

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UCN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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