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Article

NAD(+) consumption in carcinogen-treated hamster cells overexpressing a dominant negative mutant of poly(ADP-ribose) polymerase.

Biochemical and biophysical research communications - 19 Nov 1999

Küpper J H, Müller M, Wolf I

Abstract excerpt

Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins catalyzed by poly(ADP-ribose) polymerase (PARP, EC 2.4.2.30) with NAD(+) serving as substrate. PARP is activated upon binding of its aminoterminal DNA-binding domain to DNA double or single strand breaks, and is thought to play a role in cellular responses to genotoxic stress. It is known that treatment of cells with high doses of...

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Identifiers

PMID: 10558902
DOI: 10.1006/bbrc.1999.1690

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