Article
A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1.
Science (New York, N.Y.) - 7 Oct 2016
Wang Yingfei, An Ran, Umanah George K, Park Hyejin, Nambiar Kalyani, Eacker Stephen M, Kim BongWoo, Bao Lei, Harraz Maged M, Chang Calvin, Chen Rong, Wang Jennifer E, Kam Tae-In, Jeong Jun Seop, Xie Zhi, Neifert Stewart, Qian Jiang, Andrabi Shaida A, Blackshaw Seth, Zhu Heng, Song Hongjun, Ming Guo-Li, Dawson Valina L, Dawson Ted M
Abstract excerpt
Inhibition or genetic deletion of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) is protective against toxic insults in many organ systems. The molecular mechanisms underlying PARP-1-dependent cell death involve release of mitochondrial apoptosis-inducing factor (AIF) and its translocation to the nucleus, which results in chromatinolysis. We identified macrophage migration inhibitory factor (MIF) as a...
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