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Article

Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair.

Nucleic acids research - 1 Jan 2006

Bryant Helen E, Helleday Thomas

Abstract excerpt

Poly (ADP-ribose) polymerase (PARP-1), ATM and DNA-dependent protein kinase (DNA-PK) are all involved in responding to DNA damage to activate pathways responsible for cellular survival. Here, we demonstrate that PARP-1-/- cells are sensitive to the ATM inhibitor KU55933 and conversely that AT cel...

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Identifiers

PMID: 16556909
DOI: 10.1093/nar/gkl108
PMCID: PMC1410911

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16556909-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair.PMID 16556909Read ↗

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