Article
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 1997
de Murcia J M, Niedergang C, Trucco C, Ricoul M, Dutrillaux B, Mark M, Oliver F J, Masson M, Dierich A, LeMeur M, Walztinger C, Chambon P, de Murcia G
Abstract excerpt
Poly(ADP-ribose) polymerase [PARP; NAD+ ADP-ribosyltransferase; NAD+: poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyltransferase, EC 2.4.2.30] is a zinc-finger DNA-binding protein that detects specifically DNA strand breaks generated by genotoxic agents. To determine its biological f...
Topics
- Alleles
- Animals
- Apoptosis
- Cell Cycle
- Cells, Cultured
- DNA Damage
- Female
- Fibroblasts
- Gene Targeting
- Mice
- Mutation
- Poly(ADP-ribose) Polymerases
- Pregnancy