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Article

Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

Mutation research - 30 Jun 2000

Shall S, de Murcia G

Abstract excerpt

Poly (ADP-ribose) polymerase (113 kDa; PARP-1) is a constitutive factor of the DNA damage surveillance network developed by the eukaryotic cell to cope with the numerous environmental and endogenous genotoxic agents. This enzyme recognizes and is activated by DNA strand breaks. This original prop...

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PMID: 10856830
DOI: 10.1016/s0921-8777(00)00016-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10856830-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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