Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ATR and Chk1 Suppress a Caspase-3–Dependent Apoptotic Response Following DNA Replication Stress

2 Jan 2009

Abstract excerpt

The related PIK-like kinases Ataxia-Telangiectasia Mutated (ATM) and ATM- and Rad3-related (ATR) play major roles in the regulation of cellular responses to DNA damage or replication stress. The pro-apoptotic role of ATM and p53 in response to ionizing radiation (IR) has been widely investigated. Much less is known about the control of apoptosis following DNA replication stress. Recent work indicates that Chk1,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Carcinogens and Genotoxicity Assessment
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19119425
DOI: 10.1371/journal.pgen.1000324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATR and Chk1 Suppress a Caspase-3–Dependent Apoptotic Response Following DNA Replication StressPMID 19119425Read ↗

The DNA-PKcs/JNK/p53 pathway underlies changes in cell fate decision toward death during DNA replication catastropheSemantic proximity Read ↗

A synthetic lethal screen reveals enhanced sensitivity to ATR inhibitor treatment in mantle cell lymphoma with ATM loss-of-function.Semantic proximity Read ↗

Targeting Replication Stress Response Pathways to Enhance Genotoxic Chemo- and RadiotherapySemantic proximity Read ↗

Chk1 and p21 Cooperate to Prevent Apoptosis during DNA Replication Fork StressSemantic proximity Read ↗

DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.Semantic proximity Read ↗

Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agentsSemantic proximity Read ↗

Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells.Semantic proximity Read ↗

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase ActivitiesSemantic proximity Read ↗

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.Semantic proximity Read ↗

Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2Semantic proximity Read ↗

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cellsSemantic proximity Read ↗

Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.