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Local DNA damage by proton microbeam irradiation induces poly(ADP-ribose) synthesis in mammalian cells.

Mutagenesis - 1 Sept 2003

Tartier Laurence, Spenlehauer Catherine, Newman Heidi C, Folkard Melvyn, Prise Kevin M, Michael Barry D, Ménissier-de Murcia Josiane, de Murcia Gilbert

Abstract excerpt

Cellular recovery from ionizing radiation (IR)-induced damage involves poly(ADP-ribose) polymerase (PARP-1 and PARP-2) activity, resulting in the induction of a signalling network responsible for the maintenance of genomic integrity. In the present work, a charged particle microbeam delivering 3....

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PMID: 12960408
DOI: 10.1093/mutage/geg015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12960408-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Local DNA damage by proton microbeam irradiation induces poly(ADP-ribose) synthesis in mammalian cells.PMID 12960408Read ↗

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