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Article

Poly(ADP-ribose) polymerase: a new therapeutic target?

1 Apr 2008

Abstract excerpt

PURPOSE OF REVIEW: To overview the emerging data in the literature showing the role of poly(ADP-ribose) polymerase (PARP) in the pathogenesis of critical illness. RECENT FINDINGS: PARP, an abundant nuclear enzyme involved in DNA repair and transcriptional regulation, is now recognized as a key regulator of cell survival and cell death in response to noxious stimuli in various forms of cardiovascular collapse....

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PMID: 18443476
DOI: 10.1097/aco.0b013e3282f63c15

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