Article
The association of common SNPs and haplotypes in the CETP and MDR1 genes with lipids response to fluvastatin in familial hypercholesterolemia.
Atherosclerosis - 1 Mar 2006
Bercovich Dani, Friedlander Yechiel, Korem Sigal, Houminer Asaf, Hoffman Amnon, Kleinberg Lilach, Shochat Chen, Leitersdorf Eran, Meiner Vardiella
Abstract excerpt
OBJECTIVE: To examine whether genetic polymorphisms in the cholesteryl-ester transfer protein (CETP) and the P-glycoprotein drug transporter (MDR1), are associated with variable lipid response to fluvastatin. METHODS: Lipid levels were determined in a compliance-monitored clinical study at baseline and following 20 weeks of treatment with 40 mg dose of fluvastatin in 76 FH patients. CETP and MDR1 SNP genotyping...
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