Article
Haplotypes of the cholesteryl ester transfer protein gene predict lipid-modifying response to statin therapy.
The pharmacogenomics journal - 1 Jan 2003
Winkelmann B R, Hoffmann M M, Nauck M, Kumar A M, Nandabalan K, Judson R S, Boehm B O, Tall A R, Ruaño G, März W
Abstract excerpt
Cholesteryl ester transfer protein (CETP) plays a central role in high-density lipoprotein (HDL) metabolism. Single nucleotide polymorphisms (SNPs) and haplotypes in the CETP gene were determined in 98 patients with untreated dyslipidemias and analyzed for associations with plasma CETP and plasma lipids before and during statin treatment. Individual CETP SNPs and haplotypes were both significantly associated with...
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