Article
Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy.
Pharmacogenomics - 1 Sept 2008
Couvert Philippe, Giral Philippe, Dejager Sylvie, Gu Jessie, Huby Thierry, Chapman M John, Bruckert Eric, Carrié Alain
Abstract excerpt
INTRODUCTION: Marked lowering of low-density-lipoprotein cholesterol (LDL-C) levels (< or =50%) with intensive statin therapy is associated with major reduction in cardiovascular risk, but is limited by a potential increase in adverse effects, thereby justifying optimization of LDL-C reduction with minimal risk. The organic anion transporting polypeptide-1B1 encoded by the SLCO1B1 gene is implicated as a major...
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