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Article

Deletion of the beta 2 nicotinic acetylcholine receptor subunit alters development of tolerance to nicotine and eliminates receptor upregulation.

Psychopharmacology - 1 Mar 2006

McCallum Sarah E, Collins Allan C, Paylor Richard, Marks Michael J

Abstract excerpt

RATIONALE: Chronic nicotine exposure induces both tolerance and upregulation of [3H]nicotine binding sites in rodent and human brain. However, the mechanism for chronic tolerance is unclear because a direct relationship between tolerance and receptor upregulation is not consistently observed. OBJECTIVES: In the present experiments, the role of beta2* nicotinic acetylcholine receptors (nAChRs) on tolerance...

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Source

Identifiers

PMID: 16001112
DOI: 10.1007/s00213-005-0076-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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