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Article

Genotype influences the development of tolerance to nicotine in the mouse.

The Journal of pharmacology and experimental therapeutics - 1 Oct 1991

Marks M J, Campbell S M, Romm E, Collins A C

Abstract excerpt

Previous studies have demonstrated that chronic infusion of DBA/2 inbred mice with nicotine results in a dose- and time-dependent tolerance to many of the effects elicited by a challenge dose of nicotine. This tolerance was paralleled by increases in the number of brain nicotinic receptors measured with L-[3H]nicotine and alpha-[125I]bungarotoxin binding, suggesting that receptor up-regulation may underlie...

Topics

Animals
Body Temperature
Brain
Bungarotoxins
Dose-Response Relationship, Drug
Drug Tolerance
Female
Genotype
Mice
Mice, Inbred A
Mice, Inbred C3H
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred DBA

Nicotine

Receptors, Nicotinic

Reflex, Startle

Species Specificity

Source

Identifiers

PMID: 1920127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1920127-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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