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Article

Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2005

Chang-Claude Jenny, Popanda Odilia, Tan Xiang-Lin, Kropp Silke, Helmbold Irmgard, von Fournier Dietrich, Haase Wulf, Sautter-Bihl Marie Luise, Wenz Frederik, Schmezer Peter, Ambrosone Christine B

Abstract excerpt

PURPOSE: Several DNA repair gene polymorphisms have been described, which affect DNA repair capacity and modulate cancer susceptibility. We evaluated the association of six polymorphisms in the DNA repair genes: XRCC1 (Arg194Trp, Arg280His, and Arg399Gln), APE1 (Asp148Glu), and XPD (Lys751Gln and Asp312Asn), with the risk of acute skin reactions following radiotherapy. DESIGN: We conducted a prospective study of...

Topics

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Body Mass Index
DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Repair
Proportional Hazards Models

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Radiotherapy Dosage

X-ray Repair Cross Complementing Protein 1

Xeroderma Pigmentosum Group D Protein

Source

Identifiers

PMID: 16000577
DOI: 10.1158/1078-0432.CCR-04-2657

Genes

XRCC1

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