Article
Association of XRCC1 variants with acute skin reaction after radiotherapy in breast cancer patients.
Cancer biotherapy & radiopharmaceuticals - 1 Dec 2010
Zhou Liqing, Xia Jianhong, Li Hongliang, Dai Jianrong, Hu Yimin
Abstract excerpt
After irradiation results in cytotoxic effects by DNA damage, base excision repair (BER) pathway is involved in the repair of single-strand breaks and nonhomologous end joining and homologous repair of double-strand breaks caused by radiotherapy. Alterations in the function of BER DNA repair genes may affect DNA repair proficiency and influence the response of patients with cancer to radiotherapy. The association...
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