Article
Predictive value of Xrcc1 gene polymorphisms for side effects in patients undergoing whole breast radiotherapy: a meta-analysis.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012
Xie Xiao-Xue, Ouyang Shu-Yu, Jin He-Kun, Wang Hui, Zhou Ju-Mei, Hu Bing-Qiang
Abstract excerpt
Radiation-induced side effects on normal tissue are determined largely by the capacity of cells to repair radiation-induced DNA damage. X-ray repair cross-complementing group 1 (XRCC1) plays an important role in the repair of DNA single-strand breaks. Studies have shown conflicting results regarding the association between XRCC1 gene polymorphisms (Arg399Gln, Arg194Trp, -77T>C and Arg280His) and radiation-induced...
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