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Article

Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2003

Moullan Norman, Cox David G, Angèle Sandra, Romestaing Pascale, Gérard Jean-Pierre, Hall Janet

Abstract excerpt

The study goal was to examine the association of three polymorphisms in the XRCC1 gene (Arg194Trp, Arg280His, and Arg399Gln) involved in repairing DNA damage produced by ionizing radiation, a known breast cancer (BC) risk factor, with BC incidence and the possibility of developing an adverse radiotherapy response. Genomic DNA from 254 BC cases, 70 of whom were adverse radiotherapy responders [radiation-sensitive...

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Identifiers

PMID: 14652276

Genes

XRCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy.PMID 14652276Read ↗

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XRCC1 Arg399Gln, Arg194Trp and Arg280His polymorphisms in breast cancer risk: a meta-analysis.Semantic proximity Read ↗

XRCC1 R399Q polymorphism and risk of normal tissue injury after radiotherapy in breast cancer patients.Semantic proximity Read ↗

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Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to breast cancer.Semantic proximity Read ↗

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