Article
Haplotype tagging in pharmacogenetics.
Novartis Foundation symposium - 1 Jan 2005
Goldstein David B
Abstract excerpt
Analyses of variation in human populations have become central to understanding how gene variants predispose to disease and influence treatment response. Here I first describe an emerging framework for linkage disequilbrium-(haplotype) based gene mapping focusing on the analysis of patterns of genetic variation in 56 genes that metabolize or transport prescription medicines. Detailed analyses of 754 single...
Topics
- Haplotypes
- Humans
- Pharmacogenetics
- Polymorphism, Single Nucleotide