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Article

Haplotype tagging in pharmacogenetics.

Novartis Foundation symposium - 1 Jan 2005

Goldstein David B

Abstract excerpt

Analyses of variation in human populations have become central to understanding how gene variants predispose to disease and influence treatment response. Here I first describe an emerging framework for linkage disequilbrium-(haplotype) based gene mapping focusing on the analysis of patterns of genetic variation in 56 genes that metabolize or transport prescription medicines. Detailed analyses of 754 single...

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PMID: 15999798

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