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Article

Molecular determinants of S-glutathionylation of carbonic anhydrase 3.

Antioxidants & redox signaling - 1 Jan 2000

Kim Geumsoo, Levine Rodney L

Abstract excerpt

Carbonic anhydrase 3 is easily S-glutathionylated in vivo and in vitro. The protein has two surface-exposed cysteine residues that can be modified. We found that Cys186 is more readily glutathionylated than Cys181. We studied a series of site-specific mutants to identify the residues that interact with Cys186 to make its thiol more reactive. We found that Lys211 is responsible for lowering the pKa of Cys186. We...

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Identifiers

PMID: 15998239
DOI: 10.1089/ars.2005.7.849
PMCID: PMC1578687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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