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Article

Proposal for a hydrogen bond network in the active site of the prototypic gamma-class carbonic anhydrase.

Biochemistry - 25 Apr 2006

Zimmerman Sabrina A, Ferry James G

Abstract excerpt

The crystal structure of Cam, the prototypic gamma-class carbonic anhydrase, reveals active site residues Gln75, Asn73, and Asn 202 previously hypothesized to participate in catalysis. These potential roles were investigated for the first time by kinetic analyses of site-specific replacement variants of the zinc and cobalt forms of Cam. Gln75 replacement variants showed large decreases in k(cat)/K(m) relative to...

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PMID: 16618104
DOI: 10.1021/bi052507y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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