Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II.

Article

Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II.

The Journal of biological chemistry - 25 Dec 1993

Krebs J F, Ippolito J A, Christianson D W, Fierke C A

Abstract excerpt

Amino acid substitutions at Thr199 of human carbonic anhydrase II (CAII) (Thr199-->Ser, Ala, Val, and Pro) were characterized to investigate the importance of a conserved hydrogen bonding network. The three-dimensional structures of azide-bound and sulfate-bound T199V CAIIs were determined by x-r...

Topics

Amino Acids
Carbon Dioxide
Carbonic Acid
Carbonic Anhydrases
Crystallography, X-Ray
Esterases
Humans
Hydrogen Bonding
Mutation
Structure-Activity Relationship
Water

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