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Article

Role of Trp19 and Tyr200 in catalysis by the γ-class carbonic anhydrase from Methanosarcina thermophila.

Archives of biochemistry and biophysics - 1 Jan 2013

Zimmerman Sabrina, Domsic John F, Tu Chingkuang, Robbins Arthur H, McKenna Robert, Silverman David N, Ferry James G

Abstract excerpt

Although widely distributed in Nature, only two γ class carbonic anhydrases are reported besides the founding member (Cam). Although roles for active-site residues important for catalysis have been identified in Cam, second shell residues have not been investigated. Two residues (Trp19 and Tyr200), positioned distant from the catalytic metal, were investigated by structural and kinetic analyses of replacement...

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Identifiers

PMID: 23111186
DOI: 10.1016/j.abb.2012.10.010
PMCID: PMC3534908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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