Structural, catalytic and stabilizing consequences of aromatic cluster variants in human carbonic anhydrase II.

doi:10.1016/j.abb.2013.09.001

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Structural, catalytic and stabilizing consequences of aromatic cluster variants in human carbonic anhydrase II.

Archives of biochemistry and biophysics - 1 Nov 2013

Boone Christopher D, Gill Sonika, Tu Chingkuang, Silverman David N, McKenna Robert

Abstract excerpt

The presence of aromatic clusters has been found to be an integral feature of many proteins isolated from thermophilic microorganisms. Residues found in aromatic cluster interact via π-π or C-H⋯π bonds between the phenyl rings, which are among the weakest interactions involved in protein stability. The lone aromatic cluster in human carbonic anhydrase II (HCA II) is centered on F226 with the surrounding aromatics...

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Structural, catalytic and stabilizing consequences of aromatic cluster variants in human carbonic anhydrase II.

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Structural, catalytic and stabilizing consequences of aromatic cluster variants in human carbonic anhydrase II.

Abstract excerpt

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