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Article

The Malmö International Brother Study (MIBS). Genetic defects and inhibitor development in siblings with severe hemophilia A.

Haematologica - 1 Jul 2005

Astermark Jan, Oldenburg Johannes, Escobar Miguel, White Gilbert C, Berntorp Erik

Abstract excerpt

BACKGROUND AND OBJECTIVES: The strongest risk factor identified for inhibitor development in people with severe hemophilia A is the type of factor VIII gene mutation. The objective of this study was to evaluate the mutation type dependent concordance rate of inhibitor formation in siblings. DESIGN AND METHODS: The gene defect, treatment and inhibitor history were evaluated in 113 families in which two or more...

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PMID: 15996930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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