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Article

Genetic factors influencing inhibitor development in a cohort of South African haemophilia A patients.

Haemophilia : the official journal of the World Federation of Hemophilia - 1 Sept 2014

Lochan A, Macaulay S, Chen W C, Mahlangu J N, Krause A

Abstract excerpt

A critical complication of factor VIII (FVIII) replacement therapy in Haemophilia A (HA) treatment is inhibitor development. Known genetic factors predisposing to inhibitor development include FVIII (F8) gene mutations, ethnicity, a family history of inhibitors and FVIII haplotype mismatch. The aim of this study was to characterize and correlate these genetic factors in a cohort of South African HA patients. This...

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Identifiers

PMID: 24953131
DOI: 10.1111/hae.12436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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