Article
The Malmö International Brother Study (MIBS): further support for genetic predisposition to inhibitor development in hemophilia patients.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 May 2001
Astermark J, Berntorp E, White G C, Kroner B L
Abstract excerpt
The issue of factors predisposing for inhibitor development in haemophilia patients is still largely unresolved. In an attempt to address this problem, we initiated a registry in 1996 of siblings with haemophilia and with or without a history of inhibitors. Four hundred and sixty families have accrued, of whom 388 suffer from haemophilia A and 72 haemophilia B. Twenty-five of the brother pairs are twins. The...
Topics
- Chi-Square Distribution
- Factor VIII
- Family Health
- Genetic Predisposition to Disease
- Hemophilia A
- Hemophilia B
- Humans
- Isoantibodies
- Male
- Nuclear Family
- Racial Groups
- Registries