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Article

Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2006

Zhang Zhengdong, Wang Li-E, Sturgis Erich M, El-Naggar Adel K, Hong Waun K, Amos Christopher I, Spitz Margaret R, Wei Qingyi

Abstract excerpt

PURPOSE: Alteration of the FAS/FAS ligand (FASLG) pathway regulating cell death may lead to cancer development, but the effects of functional promoter polymorphisms of the FAS and FASLG genes on risk of squamous cell carcinoma of the head and neck (SCCHN) are unknown. DESIGN: We genotyped the FAS -1377 G>A, FAS -670 A>G, FASLG -844 C>T, and FASLG IVS2nt -124 A>G polymorphisms in 721 case patients with SCCHN and...

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Share to Aged, 80 and over
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Death

Share to Disease Progression

Share to Fas Ligand Protein

Share to fas Receptor

Share to Genetics, Population

Share to Head and Neck Neoplasms

Source

Identifiers

PMID: 17000697
DOI: 10.1158/1078-0432.CCR-05-1739

Genes

FAS
FASLG

Provenance

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