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Article

Polymorphisms of death pathway genes FAS and FASL in esophageal squamous-cell carcinoma.

Journal of the National Cancer Institute - 7 Jul 2004

Sun Tong, Miao Xiaoping, Zhang Xuemei, Tan Wen, Xiong Ping, Lin Dongxin

Abstract excerpt

BACKGROUND: The FAS receptor-ligand system is a key regulator of apoptotic cell death, and loss of FAS expression and gain of FAS ligand (FASL) expression play important roles in the development and progression of cancer. Single-nucleotide polymorphisms in the promoter region of the FAS (G or A at position -1377 [FAS -1377G/A] and A or G at position -670 [FAS -670A/G]) and FASL (T or C at position -844 [FASL...

Read the complete abstract on PubMed

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

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Share to Intracellular Signaling Peptides and Proteins

Share to Membrane Glycoproteins

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Source

Identifiers

PMID: 15240787
DOI: 10.1093/jnci/djh187

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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