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Article

Protective role for cytosolic phospholipase A2alpha in autoimmune diabetes of mice.

FEBS letters - 18 Jul 2005

Oikawa Y, Yamato E, Tashiro F, Yamamoto M, Uozumi N, Shimada A, Shimizu T, Miyazaki J

Abstract excerpt

Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) plays an important role in arachidonate pathway. To investigate the contribution of cPLA(2)alpha to autoimmune diabetes, we established non-obese diabetic (NOD) mouse, an excellent model for human type 1 diabetes, deficient in cPLA(2)alpha. These mice showed severe insulitis and a higher incidence of diabetes. In their macrophages, decreased prostaglandin E(2)...

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Share to Mice, Inbred NOD
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Enzyme-Linked Immunosorbent Assay

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Share to Macrophages, Peritoneal

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Source

Identifiers

PMID: 15996660
DOI: 10.1016/j.febslet.2005.06.024

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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