Article
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
Proceedings of the National Academy of Sciences of the United States of America - 10 May 2005
Jaeschke Anja, Rincón Mercedes, Doran Beth, Reilly Judith, Neuberg Donna, Greiner Dale L, Shultz Leonard D, Rossini Aldo A, Flavell Richard A, Davis Roger J
Abstract excerpt
The c-Jun NH(2)-terminal kinase isoform (JNK) 1 is implicated in type 2 diabetes. However, a potential role for the JNK2 protein kinase in diabetes has not been established. Here, we demonstrate that JNK2 may play an important role in type 1 (insulin-dependent) diabetes that is caused by autoimmune destruction of beta cells. Studies of nonobese diabetic mice demonstrated that disruption of the Mapk9 gene (which...
Topics
Join the communities discussing this publication.