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Article

Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.

Proceedings of the National Academy of Sciences of the United States of America - 10 May 2005

Jaeschke Anja, Rincón Mercedes, Doran Beth, Reilly Judith, Neuberg Donna, Greiner Dale L, Shultz Leonard D, Rossini Aldo A, Flavell Richard A, Davis Roger J

Abstract excerpt

The c-Jun NH(2)-terminal kinase isoform (JNK) 1 is implicated in type 2 diabetes. However, a potential role for the JNK2 protein kinase in diabetes has not been established. Here, we demonstrate that JNK2 may play an important role in type 1 (insulin-dependent) diabetes that is caused by autoimmune destruction of beta cells. Studies of nonobese diabetic mice demonstrated that disruption of the Mapk9 gene (which...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15867147
DOI: 10.1073/pnas.0502143102
PMCID: PMC1100789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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