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Article

Transcriptional Regulation of Type I Diabetes by NF-κB

1 Nov 2003

Abstract excerpt

Development of type I diabetes requires coordinated expression of myriad genes responsible for the initiation and progression of the disease. Expression of these genes are regulated by a small number of transcription factors including the Rel/NF-kappaB family. To determine the roles of the Rel/NF-kappaB family in type I diabetes, we studied multiple low-dose streptozotocin-induced diabetes in mice deficient in...

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PMID: 14568969
DOI: 10.4049/jimmunol.171.9.4886

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