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BamHI‐A rightward frame 1, an Epstein–Barr virus‐encoded oncogene and immune modulator

31 Aug 2013

Abstract excerpt

Epstein-Barr virus (EBV) causes several benign and malignant disorders of lymphoid and epithelial origin. EBV-related tumors display distinct patterns of viral latent gene expression, of which the BamHI-A rightward frame 1 (BARF1) is selectively expressed in carcinomas, regulated by cellular differentiation factors including ΔNp63α. BARF1 functions as a viral oncogene, immortalizing and transforming epithelial...

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PMID: 23996634
DOI: 10.1002/rmv.1758

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