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Article

Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2.

Science (New York, N.Y.) - 28 Apr 1995

Hsieh J J, Hayward S D

Abstract excerpt

Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) is a transcriptional activator that is essential for EBV-driven B cell immortalization. EBNA2 is targeted to responsive promoters through interaction with a cellular DNA binding protein, C promoter binding factor 1 (CBF1). A transcriptional repression domain has been identified within CBF1. This domain also interacts with EBNA2, and repression is masked by EBNA2...

Topics

Antigens, Viral
DNA-Binding Proteins
Epstein-Barr Virus Nuclear Antigens
Gene Expression Regulation
HeLa Cells
Humans
Immunoglobulin J Recombination Signal Sequence-Binding Protein
Models, Genetic
Mutation
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Trans-Activators

Transcription, Genetic

Transfection

Source

Identifiers

PMID: 7725102
DOI: 10.1126/science.7725102

Genes

RBPJ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7725102-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2.PMID 7725102Read ↗

A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 independent.Semantic proximity Read ↗

Both Epstein-Barr Viral Nuclear Antigen 2 (EBNA2) and Activated Notch1 Transactivate Genes by Interacting with the Cellular Protein RBP-JκSemantic proximity Read ↗

RBP-J<sub>k</sub>repression activity is mediated by a co-repressor and antagonized by the Epstein-Barr virus transcription factor EBNA2Semantic proximity Read ↗

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The Cooperative Functions of the EBNA3 Proteins Are Central to EBV Persistence and LatencySemantic proximity Read ↗

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Identification of <i>MEF2B</i> , <i>EBF1</i> , and <i>IL6R</i> as Direct Gene Targets of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Critical for EBV-Infected B-Lymphocyte SurvivalSemantic proximity Read ↗

BamHI‐A rightward frame 1, an Epstein–Barr virus‐encoded oncogene and immune modulatorSemantic proximity Read ↗

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Epstein-Barr virus nuclear protein 2 mutations define essential domains for transformation and transactivation.Semantic proximity Read ↗

Epstein-Barr Virus Essential Antigen EBNA3C Attenuates H2AX ExpressionSemantic proximity Read ↗

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