Article

The EBNA2-EBF1 complex promotes oncogenic MYC expression levels and metabolic processes required for cell cycle progression of Epstein-Barr virus-infected B cells

2021-12-29

Abstract excerpt

<h4>ABSTRACT</h4> Epstein-Barr virus (EBV) is a human tumor virus, which preferentially infects resting human B cells. Upon infection in vitro , EBV activates and immortalizes these cells. The viral latent protein EBV nuclear antigen (EBNA) 2 is essential for B cell activation and immortalization; it targets and binds the cellular and ubiquitously expressed DNA binding protein CBF1, thereby transactivating a ple...

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Literature Corpus work: 32761dd2-9d20-51ce-8e60-ec05c7abf254
DOI: 10.1101/2021.12.29.474426

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