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Article

EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells

2 Oct 2017

Abstract excerpt

Epstein-Barr virus (EBV) infection converts resting human B cells into permanently proliferating lymphoblastoid cell lines (LCLs). The Epstein-Barr virus nuclear antigen 2 (EBNA2) plays a key role in this process. It preferentially binds to B cell enhancers and establishes a specific viral and cellular gene expression program in LCLs. The cellular DNA binding factor CBF1/CSL serves as a sequence specific...

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PMID: 28968461
DOI: 10.1371/journal.ppat.1006664

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EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cellsPMID 28968461Read ↗

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Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growthSemantic proximity Read ↗

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