Article
G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) - 1 Nov 2005
Usui Isao, Imamura Takeshi, Babendure Jennie L, Satoh Hiroaki, Lu Juu-Chin, Hupfeld Christopher J, Olefsky Jerrold M
Abstract excerpt
G protein-coupled receptor kinases (GRKs) regulate seven-transmembrane receptors (7TMRs) by phosphorylating agonist-activated 7TMRs. Recently, we have reported that GRK2 can function as a negative regulator of insulin action by interfering with G protein-q/11 alpha-subunit (Galphaq/11) signaling, causing decreased glucose transporter 4 (GLUT4) translocation. We have also reported that chronic endothelin-1 (ET-1)...
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