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Article

Dominant negative protein kinase Cbeta improves 1alpha, 25-dihydroxy vitamin D3-induced insulin resistance.

Endocrine research - 1 Nov 2003

Natsume Yoshiyuki, Ishizuka Tatsuo, Yamamoto Yoritsuna, Miura Atsushi, Kajita Kazuo, Ishizawa Masayoshi, Kawai Yasunori, Huang Yannan, Morita Hiroyuki, Uno Yoshihiro, Yasuda Keigo

Abstract excerpt

1alpha,25-Dihydroxy vitamin D3 (1,25D3) activates conventional PKC and may subsequently lead to insulin resistance. Previous studies from our laboratory have shown that pretreatment with 10 nM-10 microM 1,25D3 dose-responsively suppressed insulin-induced glucose. To assess PKC(beta)-mediated inhibition of insulin-induced glucose uptake in rat adipocytes, we preincubated with Go6976 and LY379196, conventional PKC...

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Identifiers

PMID: 14682474
DOI: 10.1081/erc-120026951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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